C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/30 (2006.01) A61K 39/015 (2006.01) A61P 33/06 (2006.01) C07K 14/445 (2006.01) C12N 1/19 (2006.01) A61K 39/00 (2006.01)
Patent
CA 2102624
The present invention relates to transmission-blocking vaccines against malaria, vaccines of the present invention containing a recombinant Pfs25 Plasmodium falciparum protein produced by yeast cells, and to yeast cells producing the protein. Mice and monkeys inoculated with the yeast-expressed Pfs25 of the present invention have developed antibodies with transmission-blocking activity. The present invention also relates to methods of preventing or treating malarial infections using the vaccines of the present invention.
Barr Philip J.
Kaslow David C.
Chiron Corporation
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
The United States Of America Represented By The Secretary Department Of Health And Human Services
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