Transmucosal administration agent containing pth

Details Transmucosal administration agent containing pth Transmucosal administration agent containing pth

A - Human Necessities

61

K

A61K 38/22 (2006.01) A61K 9/08 (2006.01) A61P 19/08 (2006.01) A61P 19/10 (2006.01)

Patent

CA 2573309

It is intended to provide a method of suppressing symptoms such as nausea in the administration of PTH and a medicinal composition capable of suppressing the same. Namely, a medicinal composition for transmucosal administration which contains hPTH or its derivative, characterized by being administered in order to elevate bone mass or bone density and suppress the onset risk of one or more symptoms selected from the group consisting of foot twitching, nausea, headache and free-floating vertigo accompanying the administration of PTH. This medicinal composition sustains both of the bone-formation effect and the bone-resorption effect of PTH.

L'invention concerne un procédé de suppression de symptômes tels que la nausée associés à l'administration de PTH et une composition médicinale capable de supprimer ceux-ci. A savoir que l'invention concerne une composition médicinale pour administration trans-muqueuse laquelle contient de la hPTH ou son dérivé, caractérisée en ce qu'elle est administrée afin d'élever la quantité de tissu osseux ou la densité osseuse et de supprimer le risque de survenue d'un ou plusieurs symptômes sélectionnés dans le groupe constitué de la contraction nerveuse des pieds, de la nausée, du mal de tête et du vertige d'angoisse accompagnant l'administration de PTH. Cette composition médicinale maintient à la fois l'effet de formation osseuse et l'effet de résorption osseuse de la PTH.

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