Transmucosal delivery devices with enhanced uptake

A - Human Necessities – 61 – K

Patent

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A61K 9/00 (2006.01)

Patent

CA 2658585

The present invention provides methods for enhancing transmucosal uptake of a medicament, e.g., fentanyl or buprenorphine, to a subject and related devices. The method includes administering to a subject a transmucosal drug delivery device comprising the medicament. Also provided are devices suitable for transmucosal administration of a medicament to a subject and methods of their administration and use. The devices include a medicament disposed in a mucoadhesive polymeric diffusion environment and a barrier environment.

La présente invention concerne des procédés permettant d'augmenter l'absorption transmuqueuse d'un médicament, notamment, du fentanyl ou de la buprénorphine, par un sujet, ainsi que des dispositifs associés. Le procédé consiste à administrer à un sujet un dispositif de distribution de médicament transmuqueuse contenant le médicament. L'invention concerne également des dispositifs appropriés à l'administration transmuqueuse d'un médicament à un sujet et des procédés permettant leur administration et leur utilisation. Les dispositifs contiennent un médicament placé dans un environnement de diffusion mucoadhésif polymérique et un environnement de barrière.

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