Transmucosal form of administration with reduced mucosal...

A - Human Necessities – 61 – K

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A61K 9/00 (2006.01)

Patent

CA 2524937

The invention relates to film-type forms of administration for the transmucosal administration of active ingredients to the human or animal body. Said forms of administration are characterised by an adaptation or approach of the pH value of the base mass used to produce the form of administration and comprising a solvent or a solvent mixture, at least one matrix-forming polymer and at least one active ingredient, to the physiological pH value of the mucosa for the application. The invention also relates to a method for producing such preparations and to the use of the same as forms of administration, especially for pharmaceutical active ingredients, in such a way that mucosal irritation is reduced or even prevented by the application of the resulting forms of administration.

L'invention concerne des formes de présentation en films pour l'administration trans-muqueuse de substances actives dans le corps humain ou animal, lesdites formes étant caractérisées en ce qu'elles présentent un pH du produit de base prévu pour la production de la forme de présentation, comprenant un solvant ou un mélange de solvants, au moins un polymère formant une matrice, et au moins un principe actif, ledit pH étant adapté au/ ou se rapprochant du/ pH physiologique de la muqueuse prévue pour l'application. L'invention concerne en outre un procédé de fabrication de telles préparations, et leur utilisation sous une forme de présentation, en particulier pour des substances actives pharmaceutiques, de telle façon que lors de l'utilisation de la forme de présentation résultante, une irritation des muqueuses soit réduite, voire, totalement supprimée.

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