Transmucosal formulations of levosimendan

Details Transmucosal formulations of levosimendan Transmucosal formulations of levosimendan

A - Human Necessities

61

K

A61K 31/50 (2006.01) A61K 9/00 (2006.01) A61K 9/70 (2006.01)

Patent

CA 2313618

Described is a method of administering transmucosally, particularly to oral or nasal mucosa, levosimendan or a pharmaceutically acceptable salt thereof to a patient. The method comprises contacting an intact mucous membrane with a source of levosimendan, and maintaining said source in contact with said mucous membrane for a sufficient time period to deliver levosimendan to the patient. Transmucosal preparations of levosimendan are also described. Levosimendan is useful in the treatment of heart failure.

L'invention concerne une méthode d'administration par voie transmuqueuse, notamment les muqueuses buccale et nasale, de lévosimendane ou d'un de ses sels pharmaceutiquement acceptables à un patient. Cette méthode consiste à mettre une muqueuse intacte en contact avec une source de lévosimendane, et à maintenir cette source en contact avec cette muqueuse durant une période de temps suffisante pour administrer le lévosimendane au patient. L'invention concerne également des préparations transmuqueuses de lévosimendane. Le lévosimendane est utile pour le traitement de l'insuffisance cardiaque.

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