Transmucosal pharmaceutical administration form

Details Transmucosal pharmaceutical administration form Transmucosal pharmaceutical administration form

A - Human Necessities

61

K

A61K 9/00 (2006.01) A61K 9/70 (2006.01)

Patent

CA 2497848

Planiform transmucosal pharmaceutical administration forms are disclosed, comprising a solid solution of the active ingredient in a phosphatidyl fraction, or a mixture of said phosphatidyl fraction with a copolymer of maleic acid and an alkyl vinyl ether. The administration forms are characterised by a low solubility in the buccal cavity, which gives a rapid and constant active ingredient release over an extended period. The above are particularly suitable for the treatment of the abuse of and dependence on addictive drugs.

L'invention concerne des formes pharmaceutiques d'administration par voie transmucosale, de forme plate, qui sont constituées d'une solution solide du principe actif dans une fraction phosphatidyle, ou bien d'un mélange de ladite fraction phosphatidyle avec un copolymère d'acide maléique et un alkylvinyléther. Les formes d'administration présentées se caractérisent par une faible solubilité dans la cavité buccale, ce qui permet une libération rapide et constante sur une plus longue période. Ces formes d'administration conviennent particulièrement pour le traitement de l'abus de drogues et de la dépendance à des drogues.

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