Transplacental delivery of oligonucleotides

Details Transplacental delivery of oligonucleotides Transplacental delivery of oligonucleotides

A - Human Necessities

01

K

A01K 67/027 (2006.01) C12N 15/11 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2303616

This invention provides synthetic oligonucleotides that are useful for transplacental delivery, the oligonucleotides being DNA or RNA or both, preferably between 12-35 nucleotides in length, having a stabilized and charged backbone and at least one chemically modified base or sugar moiety, wherein the modified base or sugar moiety facilitates transplacental delivery.

L'invention concerne des oligonucléotides synthétiques qui sont utiles pour la libération transplacentaire. Ces oligonucléotides sont constitués d'ADN ou d'ARN ou des deux à la fois, ils ont de préférence une longueur comprise entre 12 et 35 nucléotides et, en outre, ils comportent un squelette stabilisé et chargé et au moins une base ou une fraction sucre chimiquement modifiée, laquelle facilite la libération transplacentaire.

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