Transport molecules using reverse sequence hiv-tat polypeptides

Details Transport molecules using reverse sequence hiv-tat polypeptides Transport molecules using reverse sequence hiv-tat polypeptides

A - Human Necessities

61

K

A61K 47/48 (2006.01) A61K 38/16 (2006.01) A61K 47/42 (2006.01) A61K 49/00 (2006.01)

Patent

CA 2672886

This invention relates to novel transport molecules that comprise a polypeptide comprising amino acid residues arranged in a sequence that is the reverse-sequence of basic portion of the HIV-TAT protein. The novel transport polypeptides are useful for transmembrane or intracellular delivery of cargo molecules, non-limiting examples of which include polypeptides and nucleic acids. The novel transport polypeptides may be covalently or non-covalenty bound to the cargo molecules.

La présente invention concerne de nouvelles molécules de transport qui comprennent un polypeptide comprenant des résidus d'acides aminés disposés dans une séquence qui est la séquence inverse de la partie de base de la protéine TAT du VIH. Les nouveaux polypeptides de transport sont utilisés pour la pénétration transmembranaire ou intracellulaire de molécules cargos parmi lesquelles figurent, à titre d'exemples non limitatifs, des polypeptides et des acides nucléiques. Les nouveaux polypeptides de transport peuvent être liés de manière covalente ou non covalente aux molécules cargos.

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