Transport of molecules across tissue using electroporation

Details Transport of molecules across tissue using electroporation Transport of molecules across tissue using electroporation

A - Human Necessities

61

N

326/17.2

A61N 1/32 (2006.01) A61K 41/00 (2006.01) A61N 1/30 (2006.01) A61B 5/00 (2006.01)

Patent

CA 1326268

TRANSPORT OF MOLECULES ACROSS TISSUE USING ELECTROPORATION Abstract of the Disclosure An electrical process for enhancing and/or controlling transport of molecules across tissue such as human and animal skin is disclosed. The process involves the use of a high voltage, short duration electrical pulses on the tissue surface to produce electroporation. Once this effect has oc- curred, concentration, pressure or temperature gradients, or iontopheresis can be used to move molecules across the tissue. The process can be repeatedly applied without producing undesirable tissue damage or can be used to purposely cause highly limited tissue damage for the purpose of providing a desired, relatively long term molecular transport pathway. The occurrence of the electro- poration effect can be detected by monitoring the tissue for a reversible electrical breakdown, which, along with an enhanced tissue permeability, is the characteristic effect of electroporation.

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