Transpulmonary liposome for controlling drug arrival

Details Transpulmonary liposome for controlling drug arrival Transpulmonary liposome for controlling drug arrival

A - Human Necessities

61

K

A61K 9/127 (2006.01) A61K 47/24 (2006.01) A61K 47/28 (2006.01) A61K 47/32 (2006.01) A61K 47/36 (2006.01) A61P 11/00 (2006.01)

Patent

CA 2682376

It is intended to provide a liposome which is excellent in the ability to control the intrapulmonary arrival of a drug or a gene and is suitable for transpulmonary administration. By modifying the surface of a liposome by using a terminal-hydrophobic polyvinyl alcohol and/or chitosan, the retention on the pulmonary tissue surface or the migration into the pulmonary tissue of a gene or a drug encapsulated in the liposome can be appropriately controlled, which makes it possible to control the behaviors thereof in vivo.

La présente invention concerne un liposome qui a une excellente capacité à contrôler l'arrivée intrapulmonaire d'un médicament ou d'un gène et qui est adapté pour une administration transpulmonaire. En modifiant la surface d'un liposome en utilisant un alcool polyvinylique hydrophobe terminal et/ou un chitosane, la rétention sur la surface du tissu pulmonaire ou la migration à l'intérieur du tissu pulmonaire d'un gène ou d'un médicament encapsulé dans le liposome peut être contrôlée de manière appropriée, ce qui rend possible le contrôle des comportements de ceux-ci in vivo.

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