Trazodone composition for once a day adminisitiation

Details Trazodone composition for once a day adminisitiation Trazodone composition for once a day adminisitiation

A - Human Necessities

61

K

A61K 31/496 (2006.01) A61K 9/22 (2006.01) A61K 47/36 (2006.01) A61P 25/20 (2006.01) A61P 25/24 (2006.01)

Patent

CA 2616416

The invention relates to a once a day formulation of trazodone or a trazodone derivative. The formulation contains trazodone or a trazodone derivative and a controlled release excipient so that, once administered orally, the trazodone or the trazodone derivative is maintained at a therapeutic plasma concentration from at least 1 hour to at least 24 hours after initial administration. After administration, the initial therapeutic action takes effect within the first hour and lasts at least about 24 hours. This therapeutic effect remains relatively and substantially stable for the remaining period of 24 hours. The formulations can be used for treating depression and/or sleeping disorders.

L'invention concerne une formulation de trazodone ou d'un dérivé de trazodone à administration quotidienne. Ladite formulation contient du trazodone ou un dérivé de trazodone et un excipient à libération commandée, de telle manière qu'en cas d'administration par voie orale, le trazodone ou le dérivé de trazodone est maintenu à une concentration plasmique thérapeutique entre 1 h et 24 h après administration initiale. Après administration, l'action thérapeutique initiale prend effet au bout d'une heure et dure au moins 24 h. Cet effet thérapeutique reste essentiellement stable sur les 24 h. Les formulations selon l'invention peuvent être employées pour le traitement de la dépression et/ou de troubles du sommeil.

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