Treated apatite particles for medical diagnostic imaging

Details Treated apatite particles for medical diagnostic imaging Treated apatite particles for medical diagnostic imaging

A - Human Necessities

61

K

A61K 49/00 (2006.01) A61K 47/48 (2006.01) A61K 49/18 (2006.01) A61K 49/22 (2006.01) A61B 19/00 (2006.01)

Patent

CA 2120130

2120130 9307905 PCTABS00021 Treated apatite particles are disclosed for enhancing medical diagnostic imaging such as magnetic resonance imaging ("MRI"), magnetic resonance spectroscopy ("MRS"), magnetic resonance spectroscopy imaging ("MRSI"), X-ray diagnostic imaging, and ultrasound imaging. Novel coating and manufacturing techniques are disclosed to control particle size and particle aggregation resulting in compositions for organ specific imaging of the liver, spleen, gastrointestinal tract, or tissue disease states. Depending on the diagnostic imaging technique, apatite particles are treated to be paramagnetic, radiopaque, or echogenic. The apatite particles may also be fluorinated to form stable fluoroapatite compositions useful for 19F imaging. Also disclosed are diagnostic compositions and methods of performing medical diagnostic procedures which involve administering to a warm-blooded animal a diagnostically effective amount of the above-described apatite particles and then performing the medical diagnostic procedure.

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