A - Human Necessities – 61 – B
Patent
A - Human Necessities
61
B
A61B 5/055 (2006.01) A61B 6/12 (2006.01) A61B 8/08 (2006.01) A61K 49/00 (2006.01) A61K 49/04 (2006.01) A61K 49/18 (2006.01) A61K 49/22 (2006.01) A61K 51/12 (2006.01) G01R 33/28 (2006.01)
Patent
CA 2159799
Treated calcium/oxyanion-containing particles are disclosed for enhancing medical diagnostic imaging such as magnetic resonance imaging ("MRI"), magnetic resonance spectroscopy ("MRS"), magnetic resonance spectroscopy imaging ("MRSI"), X-ray diagnostic imaging, and ultrasound imaging. Novel coating and manufacturing techniques are disclosed to control particle size and particle aggregation resulting in compositions for organ specific imaging of the liver, spleen, or tissue disease states is obtained. Depending on the diagnostic imaging technique, calcium/oxyanion-containing particles are treated to be paramagnetic, radiopaque, or echogenic. Also disclosed are diagnostic compositions and methods of performing medical diagnostic procedures which involve administering to a warm-blooded animal a diagnostically effective amount of the above-described particles and then performing the medical diagnostic procedure.
Cacheris William P.
Deutsch Edward A.
Deutsch Karen F.
Meeh Linda
Nosco Dennis L.
Mallinckrodt Inc.
Osler Hoskin & Harcourt Llp
LandOfFree
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