Treating a tumor or the like with electric fields at...

A - Human Necessities – 61 – N

Patent

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A61N 1/40 (2006.01)

Patent

CA 2563817

Cells that are in the late anaphase or telophase stages of cell division are vulnerable to damage by AC electric fields that have specific frequency and field strength characteristics. The selective destruction of rapidly dividing cells can therefore be accomplished by imposing an AC electric field in a target region for extended periods of time. Some of the cells that divide while the field is applied will be damaged, but the cells that do not divide will not be harmed. This selectively damages rapidly dividing cells like tumor cells, but does not harm normal cells that are not dividing. Improved results may be achieved by using a field with two or more frequencies.

Des cellules aux stades tardifs de division cellulaire d'anaphase ou de télophase sont vulnérables aux dommages provoqués par des champs électriques à c.a. qui ont des caractéristiques déterminées de fréquence et d'intensité de champ. La destruction sélective des cellules à division rapide peut ainsi être effectuée par l'application d'un champ électrique à c.a. à une région cible pendant des périodes prolongées. Certaines cellules qui se divisent pendant que le champ est appliqué sont endommagées, mais les cellules qui ne se divisent pas ne sont pas affectées. Il est ainsi possible d'endommager sélectivement des cellules à division rapide telles que les cellules cancéreuses sans affecter les cellules saines qui ne se divisent pas. On peut obtenir de meilleurs résultats par l'utilisation d'un champ avec deux ou plusieurs fréquences.

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