Treating alzheimers using delipidated protein particles

A - Human Necessities – 61 – K

Patent

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Details

A61K 9/14 (2006.01) A61K 9/127 (2006.01) A61K 38/17 (2006.01)

Patent

CA 2496831

The present invention relates to a method for preventing, reducing the progression of, and treating Alzheimer disease (AD), by creating delipidated protein particles and lipoprotein particles including at least one of LDL, VLDL, or HDL, other particles associated with lipid transport and metabolism, and combinations thereof, and administering these delipidated particles to patients at risk of developing AD or patients diagnosed with AD. The present invention employs energy and solvents useful for extracting lipids and cholesterol from the lipid-containing plasma and forming delipidated protein particles and lipoprotein particles. The present invention uses optimal solvent systems such that the lipid is dissolved while other plasma proteins are relatively intact. The present invention also provides a method of combining plasma delipidation and particle administration with other therapeutic interventions for prevention and treatment of AD.

L'invention porte sur un procédé de prévention, de réduction de la progression et de traitement de la maladie d'Alzheimer (AD), par la création de particules de protéine dégraissées et de particules de lipoprotéine contenant au moins des particules LDL, VLDL, ou HDL, ou d'autres particules associées au transport des lipides et au métabolisme, et des combinaisons de ces lipides, et par administration de ces particules dégraissées à des patients présentant un risque de développer AD ou à d'autres patients atteints de AD. Le procédé de l'invention utilise de l'énergie et des solvants utiles à l'extraction de lipides et du cholestérol de plasma contenant des lipides et à la formation de particules de protéine dégraissées et de particules de lipoprotéine. Le procédé de l'invention utilise aussi des systèmes de solvants optimaux si bien que les lipides sont dissous alors que les protéines de plasma demeurent pratiquement intactes. L'invention concerne aussi un procédé permettant de combiner le dégraissage de plasma et l'administration de particules avec d'autres interventions thérapeutiques destinées à la prévention et au traitement de AD.

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