Treating bacteria with electric fields

Details Treating bacteria with electric fields Treating bacteria with electric fields

A - Human Necessities

61

N

A61N 1/40 (2006.01)

Patent

CA 2697012

Cells that are in the process division are vulnerable to damage by AC electric fields that have specific frequency and field strength characteristics. The selective destruction of rapidly dividing cells can therefore be accomplished by imposing an AC electric field in a target region for extended periods of time. Some of the cells that divide while the field is applied will be damaged, but the cells that do not divide will not be harmed. This selectively damages rapidly dividing cells like bacteria, but does not harm normal cells that are not dividing. Since the vulnerability of the dividing cells is strongly related to the alignment between the long axis of the dividing cells and the lines of force of the electric field, improved results can be obtained when the field is sequentially imposed in different directions.

Les cellules en cours de division cellulaire sont vulnérables aux champs électriques alternatifs présentant des caractéristiques spécifiques de fréquence et de force du champ. Une destruction sélective de cellules en cours de division rapide peut donc se réaliser an soumettant un champ électrique alternatif à une zone cible de façon prolongée. Certaines des cellules en cours de division pendant l'exposition au champ seront endommagées, mais les cellules qui ne sont pas en cours de division resteront intactes. Cela permet d'endommager les cellules à division rapide telles que les bactéries, mais sans faire de mal aux cellules qui ne sont pas en cours de division. Étant donné que la vulnérabilité des cellules en cours de division est fortement liée à l'alignement de l'axe longitudinal des cellules en cours de division par rapport aux lignes de force du champ électrique, on obtient de meilleurs résultats en appliquant le champ selon plusieurs axes d'orientation successivement.

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