G - Physics
01
N
G01N 33/574 (2006.01) A61K 31/00 (2006.01) A61K 31/337 (2006.01) A61K 33/24 (2006.01) A61K 45/00 (2006.01) A61P 35/00 (2006.01) C07K 14/47 (2006.01) C07K 16/32 (2006.01) C12N 15/09 (2006.01) C12P 21/08 (2006.01) C12Q 1/68 (2006.01) G01N 33/00 (2006.01) G01N 33/15 (2006.01) G01N 33/48 (2006.01) G01N 33/53 (2006.01) G01N 33/68 (2006.01)
Patent
CA 2321467
Provided is a method for measuring the resistance of p53 mutant cancer cells to the cytotoxic effects of a chemotherapeutic agent, which method comprises testing a sample comprising p53 mutant cells or an extract therefrom for the level of expression of Cyclin D1 or for the abundance of Cyclin D1 protein. Also provided is a kit for measuring the resistance of p53 mutant cancer cells to the cytotoxic effects of a chemotherapeutic agent, which kit comprises: i) a means for testing for the level of expression of Cyclin D1 or for the abundance of Cyclin D1 protein; and ii) a means for identifying p53 mutant cells.
L'invention concerne une technique permettant de mesurer la résistance de cellules cancéreuses mutantes p53 aux effets cytotoxiques d'un agent de chimiothérapie. Cette technique consiste à tester un échantillon comprenant des cellules mutantes p53 ou un extrait des celles-ci, de manière à déterminer le niveau d'expression de la cycline D1 ou l'abondance d'une protéine de la cycline D1. L'invention concerne également un kit permettant de mesurer la résistance de cellules cancéreuses mutantes p53 aux effets cytotoxiques d'un agent de chimiothérapie. Ce kit comprend (i) des moyens de recherche du niveau d'expression de la cycline D1 ou de l'abondance d'une protéine de la cycline D1; (ii) des moyens d'identification de cellules mutantes p53.
Fetherstonhaugh & Co.
Theryte Limited
LandOfFree
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