Treating cancer

Details Treating cancer Treating cancer

G - Physics

01

N

G01N 33/574 (2006.01) A61K 31/00 (2006.01) A61K 31/337 (2006.01) A61K 33/24 (2006.01) A61K 45/00 (2006.01) A61P 35/00 (2006.01) C07K 14/47 (2006.01) C07K 16/32 (2006.01) C12N 15/09 (2006.01) C12P 21/08 (2006.01) C12Q 1/68 (2006.01) G01N 33/00 (2006.01) G01N 33/15 (2006.01) G01N 33/48 (2006.01) G01N 33/53 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2321479

Provided is a method for measuring the resistance of cells to the cytotoxic effects of a chemotherapeutic agent, which method comprises testing a sample comprising cells or an extract therefrom for: a) the level of expression of p21, or for the abundance of p21 protein; and b) the level of expression of Cyclin D1, or for the abundance of Cyclin D1 protein. Also provided is a kit for measuring the resistance of cells to the cytotoxic effects of a chemotherapeutic agent, which kit comprises: I) a means for testing for the level of expression of p21, or for the abundance of p21 protein; and ii) a means for testing for the level of expression of Cyclin D1, or for the abundance of Cyclin D1 protein.

L'invention concerne une technique permettant de mesurer la résistance de cellules aux effets cytotoxiques d'un agent chimiothérapique. Cette technique consiste à tester un échantillon comprenant des cellules ou un extrait de celles-ci, de manière à déterminer (a) le niveau d'expression d'une protéine p21 ou l'abondance de ladite protéine; (b) le niveau d'expression de la cycline D1 ou l'abondance de cette protéine de cycline. L'invention concerne également un kit permettant de mesurer la résistance de cellules aux effets cytotoxiques d'un agent chimiothérapique. Ce kit comprend (i) des moyens de recherche du niveau d'expression d'une protéine p21 ou de l'abondance de cette protéine; (ii) des moyens de recherche du niveau d'expression de la cycline D1 ou de l'abondance de protéine de la cycline D1.

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