A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/715 (2006.01) A61K 45/06 (2006.01)
Patent
CA 2305726
Compositions and methods for treatment of occlusive peripheral vascular disease and coronary disease are disclosed. The compositions and methods allow treatment of diseases associated with occlusion of coronary vessels, for example, by promoting growth of new blood vessels, i.e., angiogenesis and/or by recruitment of collaterals. The methods involve the co-administration of an adenosine A2 receptor agonist, e.g. adenosine, and heparin and/or a heparin- like substance over a period of several days. In particular, this invention is applicable to improving collateral coronary circulation in patients suffering from myocardial infarction.
Cette invention concerne des compositions et des procédés permettant de traiter la vasculopathie périphérique oblitérante et la coronarite. Les compositions et les procédés permettent de traiter des maladies associées à l'occlusion des vaisseaux coronaires, par exemple, au moyen de l'activation de la croissance de nouveaux vaisseaux sanguins (c'est-à-dire par angiogénèse et/ou par recrutement d'artères collatérales). Le procédé consiste à coadministrer un agoniste du récepteur A¿2? adénosine, par exemple de l'adénosine et de l'héparine et/ou une substance similaire à l'héparine sur une période de plusieurs jours. D'une manière plus spécifique, cette invention peut s'appliquer pour améliorer la circulation des artères coronaires collatérales chez des patients atteints d'infarctus du myocarde.
Barron Hal V.
Botvinick Elias
Regents Of The University Of California
Smart & Biggar
LandOfFree
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