A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/40 (2006.01) A61K 9/22 (2006.01) A61K 9/52 (2006.01) A61K 31/405 (2006.01) A61K 45/06 (2006.01)
Patent
CA 2272463
Treating or preventing the early stages of degeneration of articular cartilage or subchondral bone in the affected joint of a mammal is accomplished by administering a chondroprotective compound of Formula (I): (see formula I) wherein where A is hydroxy, (C1 - C4)alkoxy, amino, hydroxy-amino, mono-(C1 - C2)alkylamino, di-(C1 - C2)alkylamino; X and Y are independently H or (C1 - C2)alkyl; and n is 1 or 2; R6 is halogen, (C1 - C3)alkyl, trifluoromethyl, or nitro; R9 is H; (C1 - C2)alkyl; phenyl or phenyl-(C1 - C2)alkyl, where phenyl is optionally mono-substituted by fluoro or chloro; -C(=O)-R, where R is (C1 - C2)alkyl or phenyl, optionally mono-substituted by fluoro or chloro; or -C(=O)- O-R1 , where R1 is (C1 - C2)alkyl.
Evans Nigel Anthony
Kilroy Carolyn Rose
Lundy Kristin Marie
Pelletier Jean-Pierre
Ricketts Anthony Paul
Pfizer Products Inc.
Smart & Biggar
LandOfFree
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