A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/445 (2006.01)
Patent
CA 2472682
The use of chemokine receptor CCR5 modulators (e.g., CCR5 antagonists) is disclosed for the treatment or prevention of stress response (e.g., fever) in a subject resulting from surgery, infection or other insult to the subject (e.g., a warm-blooded vertebrate). Methods for treating or preventing disorders involving the activation of pro-inflammatory cytokines by administration of a CCR5 modulator, for inhibiting the endogenous production of pro-inflammatory cytokines by the administration of CCR5 modulators, and for determining the efficacy of CCR5 modulators in correcting abnormal levels of pro-inflammatory cytokines are also disclosed.
La présente invention concerne l'utilisation des modulateurs CCR5 du récepteur de chimiokine (par exemple, des antagonistes CCR5) pour le traitement ou la prévention de la réaction de stress (par exemple, la fièvre) chez un sujet à une intervention chirurgicale, une infection ou autre attaque sur un sujet (par exemple, un vertébré à sang chaud). L'invention concerne également des procédés de traitement et de prévention des troubles impliquant l'activation de cytokines pro-inflammatoires par l'administration d'un modulateur CCR5, pour l'inhibition de la production endogène de cytokines pro-inflammatoires par l'administration de modulateurs CCR5, et pour la détermination de l'efficacité des modulateurs CCR5 dans la correction des niveaux anormaux de cytokines pro-inflammatoires.
Azimzadeh Agnes M.
Demartino Julie A.
Pierson Richard N. III
Schroeder Carsten
Merck & Co. Inc.
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
Vanderbilt University
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