A - Human Necessities – 61 – L
Patent
A - Human Necessities
61
L
A61L 33/00 (2006.01) A61L 29/08 (2006.01) A61L 31/10 (2006.01) A61L 33/06 (2006.01)
Patent
CA 2460631
A metal, glass or ceramics article, for example a stent, having at its surface oxide or hydroxide is treated to enhance the biocompatibility and/or physical characteristics of the surface. The surface is de-greased and primed by contact with an alkoxysilane in a aprotic organic solvent in the presence of an acid catalyst so that the alkoxysilance molecules react with the oxide or hydroxide of said surface to form covalent bonds, the alkoxysilane further comprising one or more amino, hydroxyl, carboxylic acid or acid anhydride groups. A polymer, e.g. carbodymethyl cellulose, is then covalently coupled to said surface via said amino, hydroxyl, carboxylic acid or acid anhydride groups, after which biologically active materials may be coupled to the polymer. Such materials may include an anti-coagulating agent or anti-platelet agent and an agent that inhibits smooth cell proliferation and restenosis.
On traite un article en métal, en verre ou en céramique, tel qu'une endoprothèse, possédant à sa surface de l'oxyde ou de l'hydroxyde, pour améliorer la biocompatibilité et/ou les caractéristiques physiques de ladite surface. On dégraisse et on apprête la surface en la mettant en contact avec un alcoxysilane dans un solvant organique aprotique, en présence d'un catalyseur acide, de sorte que l'alcoxysilane réagisse avec l'oxyde ou l'hydroxyde de ladite surface pour former des liaisons covalentes, l'alcoxysilane comprenant ensuite un ou plusieurs groupes amino, hydroxyle, d'acide carboxylique ou d'anhydride d'acide. On couple ensuite de manière covalente un polymère, tel qu'une cellulose carboxyméthylique, à ladite surface, par l'intermédiaire desdits groupes amino, hydroxyle, d'acide carboxylique et d'anhydride d'acide, après quoi les matières actives au plan biologique peuvent être couplées au polymère. Lesdites matières peuvent inclure un agent anticoagulant ou un agent antiplaquettaire et un agent qui inhibe la prolifération cellulaire homogène et la resténose.
Al-Lamee Kadem Gayed
Bayes Stuart
Cook Diane
Lott Martyn Peter
Bayer Materialscience Ag
Mcfadden Fincham
Polybiomed Limited
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