C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 213/08 (2006.01) A61K 31/215 (2006.01) A61K 31/216 (2006.01) A61P 13/00 (2006.01) C07C 219/20 (2006.01)
Patent
CA 2211400
A method for treating urinary incontinence while avoiding concomitant liability of adverse effects associated with racemic oxybutynin is disclosed. The method comprises administering a therapeutically effective amount of (S)-oxybutynin, (S)-desethyloxybutynin or a pharmaceutically acceptable salt thereof, substantially free of the corresponding R enantiomer. Pharmaceutical compositions in the form of tablets and transdermal devices comprising (S)-oxybutynin or (S)- desethyloxybutynin and an acceptable carrier are also disclosed, as is a synthesis of desethyloxybutynin.
L'invention décrit un procédé pour traiter l'incontinence urinaire en évitant le risque concomitant d'effets indésirables associés à l'oxybutynine racémique. Ledit procédé consiste à administrer une quantité thérapeutiquement efficace de (S)-oxybutynine, de (S)-déséthyloxybutynine ou d'un sel pharmaceutiquement acceptable de celles-ci, pratiquement exempte de l'énantiomère R correspondant. L'invention décrit également des compositions pharmaceutiques sous forme de comprimés et de dispositifs transdermiques contenant de la (S)-oxybutynine ou de la (S)-déséthyloxybutynine, ainsi qu'un excipient acceptable tel qu'une synthèse de déséthyloxybutynine.
Aberg Gunnar
Fang Yue
Mc Cullough John R.
Gowling Lafleur Henderson Llp
Sepracor Inc.
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