Treatment and diagnosis of a reproductive disorder by...

A - Human Necessities – 61 – K

Patent

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A61K 38/21 (2006.01) A61K 38/18 (2006.01) A61P 15/00 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2539477

The invention provides compositions and methods for diagnosing and treating reproductive disorders. The invention also provides methods for diagnosing reproductive disorders by detecting the presence of IFN-.gamma. in the semen of a prospective father, which is indicative of the presence of a reproductive disorder. In particular, the invention provides a method for treating a reproductive disorder in a mammal, comprising administering an effective amount of a compound which inhibits the activity of IFN.gamma. to the mammal. The mammal may be the prospective mother or the prospective father.

La présente invention concerne des compositions et des méthodes permettant de diagnostiquer et de traiter des troubles de la reproduction. Cette invention concerne également des méthodes permettant de diagnostiquer des troubles de la reproduction par détection de la présence d'IFN-.gamma. dans sperme d'un éventuel père; cette présence indiquant un trouble de la reproduction. Plus particulièrement, cette invention concerne une méthode permettant de traiter un trouble de la reproduction chez un mammifère, laquelle méthode consiste à administrer, à un mammifère, une quantité efficace d'un composé inhibant l'activité de l'IFN-.gamma.. Le mammifère peut être le père ou la mère.

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