Treatment and diagnostic methods for hypersensitive disorders

A - Human Necessities – 61 – K

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A61K 38/00 (2006.01) A61K 39/00 (2006.01) A61P 11/06 (2006.01) A61P 29/00 (2006.01) A61P 37/00 (2006.01)

Patent

CA 2754961

The current standard of care for the treatment of allergic airway diseases include short and long acting beta-agonists, and inhaled or systemic corticosteroids, cromolyn and xanthines that all have the potential of detrimental side-effects. The present invention describes a new mechanistic protein-based therapeutic approach for the treatment of allergic airway disease and diseases associated with excessive Th2 pathology. The present invention relates to the surprising discovery that serum amyloid P (SAP) demonstrates a therapeutic affect in the treatment of hypersensitive disorders.

L'invention concerne des procédés de traitement et de diagnostic pour troubles d'hypersensibilité. Les soins standards actuels pour le traitement des maladies allergiques des voies respiratoires incluent les agonistes bêta à action courte et longue, et les corticostéroïdes, la cromolyne et les xanthines inhalés ou systémiques, qui ont tous des effets secondaires indésirables potentiels. La présente invention décrit une nouvelle approche thérapeutique mécanistique à base de protéines pour le traitement des maladies allergiques des voies respiratoires et des maladies associées avec une pathologie Th2 excessive. La présente invention concerne la découverte surprenante selon laquelle l'amyloïde P sérique (SAP) présente un effet thérapeutique dans le traitement des troubles d'hypersensibilité.

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