Treatment and prevention of adhesions

Details Treatment and prevention of adhesions Treatment and prevention of adhesions

A - Human Necessities

61

K

A61K 31/517 (2006.01) A61K 31/513 (2006.01) A61P 41/00 (2006.01)

Patent

CA 2279939

An inhibitor of adhesion formation which can be used to prevent adhesions within the abdominal cavity, particularly following surgical intervention in the area. Specifically, the most preferred compound of the present invention, Halofuginone, can be used to prevent collagen deposition from occurring within the peritoneum after such surgical intervention, thereby inhibiting adhesion formation. Halofuginone, and related compounds, are useful in the prevention and treatment of both inflammatory and surgically induced adhesions, and in the treatment of congenital adhesions.

L'invention concerne un inhibiteur de la formation d'adhérences, que l'on peut utiliser pour empêcher les adhérences dans la cavité abdominale, notamment après une intervention chirurgicale pratiquée dans cette zone. On peut utiliser, plus particulièrement, le composé préféré de l'invention, à savoir Halofuginone, pour empêcher tout dépôt de collagène de se produire dans le péritoine après une intervention chirurgicale au niveau de celui-ci, empêchant ainsi la formation d'adhérences. L'halofuginone et des composés associés sont utiles dans la prévention et le traitement des adhérences induites à la fois de façon inflammatoire et chirurgicale, et dans le traitement des adhérences congénitales

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