Treatment and prevention of cardiac conditions using two or...

A - Human Necessities – 61 – K

Patent

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Details

A61K 38/18 (2006.01) A61K 31/70 (2006.01) A61K 31/7088 (2006.01) A61P 9/10 (2006.01)

Patent

CA 2712078

The present invention relates to methods for treating or preventing car-diac conditions in a subject comprising ad-ministering to the subject two or more iso-forms of hepatocyte growth factor (HGF). The present invention further relates to methods for promoting endothelial cell growth in a blood vessel comprising admin-istering to the blood vessel two or more iso-forms of hepatocyte growth factor (HGF). In one embodiment the two or more iso-forms of HGF are administered as one or more polynucleotides encoding the iso-forms.

La présente invention concerne des méthodes de traitement ou de prévention d'états cardiaques chez un sujet, consistant à administrer au sujet au moins deux isoformes du facteur de croissance des hépatocytes (HGF). La présente invention concerne également des méthodes favorisant la croissance des cellules endothéliales dans un vaisseau sanguin, consistant à administrer dans le vaisseau sanguin au moins deux isoformes du facteur de croissance des hépatocytes (HGF). Dans un mode de réalisation, au moins deux isoformes du HGF sont administrées, ainsi qu'un ou plusieurs polynucléotides codant pour les isoformes.

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