Treatment and prevention of ebv infection and ebv-associated...

Details Treatment and prevention of ebv infection and ebv-associated... Treatment and prevention of ebv infection and ebv-associated...

A - Human Necessities

61

K

A61K 39/395 (2006.01) C07K 14/15 (2006.01) C07K 16/08 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2429755

The present invention provides substances suitable for use as vaccines for the prevention of EBV infection and EBV-associated disorders and methods for administering them. The vaccines are directed against HERV-K18 env (SEQ ID:1) and most preferably comprise antigens obtained from HERV-K18 env. Preferred antigens include SEQ ID:2, SEQ ID:3 and SEQ ID:4. Most preferably, the SAg T cell stimulatory activity of the HERV-K18 env is diminished or eliminated. In another embodiment, the vaccine contains a nucleic acid encoding HERV-K18 env or an immunogenic fragment thereof. The present invention also provides methods for treating EBV infection and EBV-associated disorders.

La présente invention concerne des substances adaptées pour être utilisées comme vaccins pour la prévention de l'infection du virus EBV et des troubles qui lui sont associés, ainsi que des méthodes d'administration de ces substances. Les vaccins sont dirigés contre le rétrovirus endogène humain HERV-K18 env (SEQ ID:1) et, idéalement, comprennent des antigènes obtenus à partir du HERV-K18 env. Les antigènes préférés comprennent les séquences SEQ ID:2, SEQ ID:3 et SEQ ID:4. Idéalement, l'activité stimulante des superantigènes des lymphocytes T du HERV-K18 env est réduite ou supprimée. Dans un autre mode de réalisation, le vaccin comprend un acide nucléique codant le HERV-K18 env ou un fragment immunogène de ce dernier. La présente invention concerne également des méthodes de traitement de l'infection par le virus EBV et des troubles qui lui sont associés.

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