A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/55 (2006.01) A61K 9/20 (2006.01) A61K 31/24 (2006.01) A61K 31/65 (2006.01)
Patent
CA 2587516
The present invention is directed to a method of treating or preventing epileptic seizures in a subject and a method of inhibiting hypersynchronous burst activity of neurons by administering an agent which interferes with glutamate, aspartate, and/or ATP release from astrocytes. Also presented is a method of identifying agents suitable for treating or preventing epileptic seizures.
La présente invention concerne un procédé de traitement ou de prévention de crises d'épilepsie chez un sujet, et une méthode pour inhiber une activité sporadique hypersynchrone des neurones, par administration d'un agent qui interfère avec le glutamate, l'aspartate et/ou la libération d'ATP par les astrocytes. L'invention concerne en outre une méthode d'identification d'agents pouvant traiter ou prévenir de manière appropriée les crises d'épilepsie.
Nedergaard Maiken
Tian Guo Feng
Gowling Lafleur Henderson Llp
University Of Rochester
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