Treatment and prophylaxis of amyloidosis

C - Chemistry – Metallurgy – 07 – K

Patent

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Details

C07K 16/18 (2006.01) A61K 39/00 (2006.01) A61K 39/395 (2006.01) A61K 49/00 (2006.01) A61K 49/16 (2006.01) A61K 51/00 (2006.01) A61K 51/10 (2006.01) C07K 14/775 (2006.01) C07K 16/46 (2006.01)

Patent

CA 2710984

Methods useful for effecting prophylaxis or treatment of amyloidosis, including AA Amyloidosis and AL amyloidosis, by administering peptides comprising neoepitopes, such as AA fragments from a C-terminal region of AA, and antibodies specific for neoepitopes of aggregated amyloid proteins, for example, antibodies specific for the C-terminal region of AA fibrils. Antibodies for inhibition of formation and/or increasing clearance of amyloid deposits in a patient thus effecting prophylaxis or treating amyloid disease.

La présente invention concerne des procédés permettant de réaliser une prophylaxie ou un traitement de l'amylose, y-compris de l'amylose AA et de l'amylose AL. Ce procédé consiste en l'administration de peptides comprenant des néo-épitopes, tels que des fragments AA provenant d'une région terminale C d'AA, et des anticorps spécifiques de néo-épitopes de protéines amyloïdes agrégées, par exemple, des anticorps spécifiques de la région terminale C de fibrilles AA. L'invention concerne également des anticorps destinés à inhiber la formation et/ou à augmenter la clairance des dépôts d'amyloïdes chez un patient, réalisant ainsi une prophylaxie ou un traitement de l'amylose.

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