C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/11 (2006.01) A61K 31/7088 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2717169
miRNAs that regulate human SPARC and methods of use thereof are described. Suitable nucleic acids for use in the methods and compositions described herein include, but are not limited to, pri-miRNA, pre-miRNA, ds miRNA, mature miR-NA or fragments of variants thereof that retain the biological activity of the mature miRNA and DNA encoding a pri-miRNA, pre-miRNA, mature miRNA, fragments or variants thereof, or regulatory elements of the miRNA.
L'invention porte sur des ARNmi qui régulent SPARC humain et sur leurs procédés d'utilisation. Les acides nucléiques appropriés pour une utilisation dans les procédés et des compositions décrites ici comprennent, mais sans y être limités, des pri-ARNmi, pre-ARNmi, ARNmi ds, ARNmi mature ou fragments de variants de ceux-ci qui conservent l'activité biologique de l'ARNmi mature et de l'ADN codant pour un pri-ARNmi, pre-ARNmi, ARNmi mature, fragments ou variants de ceux-ci, ou des éléments régulateurs de l'ARNmi.
Desai Neil
Hwang Larn
Trieu Vuong
Abraxis Bioscience Llc
Ridout & Maybee Llp
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