Treatment for cd5+ b cell lymphoma

Details Treatment for cd5+ b cell lymphoma Treatment for cd5+ b cell lymphoma

A - Human Necessities

61

K

A61K 38/20 (2006.01) A61K 31/4745 (2006.01) A61K 45/06 (2006.01)

Patent

CA 2537763

The present invention provides methods for increasing expression of cell surface molecules of CD5+ B cell lymphoma cells by contacting cells with immune response modifiers. The invention also provides methods for the treatment of CD5+ B cell lymphomas, including chronic lymphocytic leukemia and small lymphocytic lymphoma, by administering immune response modifier compounds to a subject in need of such treatment. Suitable immune response modifier compounds include agonists of TLR7 and/or TLR8.

La présente invention a trait à des procédés pour l'accroissement de l'expression des molécules de surface cellulaires des cellules du lymphome à cellules B CD5?+¿ par la mise en contact des cellules avec des gènes modificateurs de la réponse immunitaire. L'invention a également trait à des procédés pour le traitement des lymphomes à cellules B CD5?+¿, y compris la leucémie lymphocytaire chronique et le lymphome à petits lymphocytes, par l'administration des composés de gènes modificateurs de la réponse immunitaire à un sujet nécessitant un tel traitement. Des composés appropriés de gènes modificateurs de la réponse immunitaire comprennent des agonistes de TLR7 et/ou de TLR8.

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