A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/43 (2006.01) A61K 38/46 (2006.01) A61K 38/48 (2006.01) A61K 41/00 (2006.01) A61K 49/00 (2006.01)
Patent
CA 2491128
The present invention relates to altering the physical and/or chemical properties of at least part of at least one tissue in the eye. In a specific embodiment, it relates to the treatment of any eye disorder, although in particular embodiments the individual has a thickened Bruch's membrane. An activating energy source is utilized to effect a controlled diffusion enhancement and/or degradation of Bruch's membrane that enables improved diffusional transport between the choroid and retina. The individual is administered an inactivated diffusion-enhancing molecule that becomes associated with the membrane, which is then precisely exposed to an activating energy source, such as light or ultrasound.
L'invention concerne la modification de propri~t~s physiques et/ou chimiques d'au moins une partie d'au moins un tissu de l'oeil. Selon un mode de r~alisation sp~cifique, on d~crit le traitement d'un trouble oculaire quelconque, mais le sujet pr~sente une membrane de Bruch ~paissie selon des variantes particulires de l'invention. Une source d'~nergie d'activation induit par diffusion une am~lioration et/ou une d~gradation contrÙl~e de la membrane de Bruch, permettant d'am~liorer le transport par diffusion entre la choro~de et la r~tine. On administre au sujet une mol~cule d'am~lioration de la diffusion inactiv~e s'associant ~ la membrane, que l'on expose ensuite de fa×on cibl~e ~ une source d'~nergie d'activation, du type lumineuse ou ultrasonore.
Fraser Scott
Gallivan Justin P.
Grubbs Robert H.
Schwartz Daniel M.
Yu Changjun
Borden Ladner Gervais Llp
The California Institute Of Technology
The Regents Of The University Of California
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