Treatment for tissue ulceration

Details Treatment for tissue ulceration Treatment for tissue ulceration

A - Human Necessities

61

K

A61K 31/405 (2006.01) A61K 31/16 (2006.01) A61K 31/445 (2006.01) A61K 38/05 (2006.01) C07C 271/02 (2006.01) C07D 209/26 (2006.01) C07K 5/078 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2096223

Compounds of formulae (1) or (2) wherein R1 is H and R2 is alkyl (3-8C) or wherein R1 and R2 taken together are -(CH2)n- wherein n = 3-5; R3 is H or alkyl (1-4C); R4 is a substituted or unsubstituted fused or conjugated bicycloaryl methylene; X is OR5 or NHR5, wherein R5 is H or substituted or unsubstituted alkyl (1-12C), aryl (6-12C), aryl alkyl (6-16); or X is an amino acid residue or amide thereof; or X is the residue of a cyclic amine or heterocyclic amine are use- ful for treating or preventing ulceration of tissue, especially cornea.

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