Treatment for verotoxin-producing escherichia coli

A - Human Necessities – 61 – K

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Details

A61K 39/40 (2006.01) C07K 14/245 (2006.01) C07K 16/02 (2006.01) C07K 16/12 (2006.01) G01N 33/569 (2006.01) A61K 38/00 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2218601

The present invention includes methods for generating neutralizing antitoxin directed against verotoxins. In particular, the antitoxin directed against these toxins is produced in avian species using soluble recombinant verotoxin proteins. This avian antitoxin is designed so as to be administrable in therapeutic amounts and may be in any form (i.e., as a solid or in aqueous solution). These antitoxins are useful in the treatment of humans and other animals intoxicated with at least one bacterial toxin, as well as for diagnostic assays to detect the presence of toxin in a sample.

L'invention concerne des méthodes de production d'une antitoxine neutralisante dirigée contre les vérotoxines. Plus particulièrement, on produit l'antitoxine dirigée contre ces toxines dans des espèces aviaires en utilisant des protéines de vérotoxines recombinées solubles. Cette antitoxine aviaire est destinée à être administrée en doses thérapeutiques et peut se présenter sous quelle que forme que ce soit, sous forme solide ou dans une solution aqueuse. Ces antitoxines sont utiles dans le traitement d'humains et d'autres animaux intoxiqués par au moins une toxine bactérienne ainsi que pour des méthodes diagnostiques pour la détection de la présence d'une toxine dans un échantillon.

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