Treatment kit to assist in antibiotic therapy in...

A - Human Necessities – 61 – K

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Details

A61K 38/19 (2006.01) A61K 31/455 (2006.01) A61K 38/18 (2006.01) A61P 31/00 (2006.01)

Patent

CA 2525539

The invention relates to the use of immunomodulators in order to help with standard treatment against infectious diseases caused by facultative intracellular organisms. The invention is based on an analysis of the immune response established during said type of infections and, in particular, that produced by tuberculosis. Taking account of the aforementioned analysis, the invention consists in using a treatment kit associating a soluble betaglycan- type immunomodulator with an anti-inflammatory agent of the prostaglandin E- blocker type, which, when used together, modulate the immune response, thereby enabling the treatment time with respective antibiotics to be shortened.

La présente invention concerne l'utilisation d'immunomodulateurs pour renforcer un traitement classique contre des maladies infectieuses occasionnées par des organismes intracellulaires facultatifs. L'invention consiste à utiliser, sur la base de l'analyse de la réponse immunitaire déclenchée dans ces types d'infections et, plus particulièrement, de la réponse immunitaire déclenchée par la tuberculose, un kit de traitement comprenant un immunomodulateur du type bêta-glycane soluble, associé à un agent anti-inflammatoire du type des bloqueurs de la prostaglandine E. L'immunomodulateur et l'agent anti-inflammatoire, lorsqu'ils sont utilisés conjointement, modulent la réponse immunitaire et permettent de raccourcir le temps de traitement avec les antibiotiques respectifs.

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