A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/55 (2006.01) A61K 31/506 (2006.01)
Patent
CA 2631173
The present invention is directed to methods of treating an ocular neovascular disorder in a mammal by administration of pyrimidine derivatives, benzodiazepinyl derivatives and pharmaceutical compositions containing the same. The invention encompasses methods of treating an ocular neovascular disorder by administration of 5-[[4-[(2,3-Dimethyl-2H-indazol-6- yl)methylamino]-2-pyrimidinyl]amino]-2-methylbenzenesulfonamide, (S)-3-oxo-8- [3-(pyridin-2-ylamino)-1-propyloxy]-2-(2,2,2-trifluoroethyl)-2,3,4,5- tetrahydro-1H-2-benzazepine-4-acetic acid or salts or solvates thereof. Combination therapies for the treatment of ocular neovascular disorders are also encompassed.
La présente invention concerne des procédés de traitement d'un trouble néovasculaire oculaire chez un mammifère par l'administration de dérivés de pyrimidine, de dérivés de benzodiazépinyle et des compositions pharmaceutiques en contenant. L'invention concerne également des procédés de traitement d'un trouble néovasculaire oculaire par l'administration de l'acide 5-[[4-[(2,3-diméthyl-2H-indazol-6-yl)méthylamino]-2-pyrimidinyl]amino]-2-méthylbenzenesulfonamide, (S)-3-oxo-8-[3-(pyridin-2-ylamino)-1-propyloxy]-2-(2,2,2-trifluoroéthyl)-2,3,4,5-tétrahydro-1H-2-benzazépine-4-acétique ou des sels et des solvates de celui-ci. L'invention concerne en outre des thérapies de combinaison pour le traitement de troubles néovasculaires oculaires.
Brigandi Richard Anthony
Levick Mark
Miller William Henry
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
Smithkline Beecham Corporation
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