Treatment method for cancer

A - Human Necessities – 61 – K

Patent

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Details

A61K 31/535 (2006.01) A61K 31/13 (2006.01) A61K 31/135 (2006.01) A61K 31/17 (2006.01) A61K 31/335 (2006.01) A61K 31/505 (2006.01) A61K 45/06 (2006.01) A61K 47/18 (2006.01) A61K 47/22 (2006.01)

Patent

CA 2098593

The in vivo chemotherapeutic treatment of cancer cells in a living animal is improved by first administering to the animal an antagonist specific for intracellular histamine in an amount sufficient to inhibit the binding of intracellular histamine in normal cells. An enhanced toxic effect on the cancer cells from the chemotherapeutic agent is obtained while any adverse effect of the chemotherapeutic agent on normal cells is inhibited. In addition, long term continuous administration of the antagonist following administration of the chemotherapeutic agent results in at least amelioration of the adverse side effects of chemotherapy. The treatment of cancer cells using DPPE specifically illustrates the invention.

On peut améliorer le traitement chimiothérapeutique in vivo des cellules cancéreuses chez un animal vivant en administrant à l'animal un antagoniste spécifique de l'histamine intracellulaire dans une quantité suffisante pour inhiber la liaison de l'histamine intracellulaire dans les cellules normales. On obtient un effet toxique amélioré sur les cellules cancéreuses avec l'agent chimiothérapeutique, tout en inhibant un quelconque effet néfaste dudit agent sur les cellules normales. Par ailleurs, l'administration de l'agent chimiothérapeutique entraîne au moins une amélioration des effets secondaires néfastes de la chimiothérapie. L'invention est représentée de manière spécifique par le traitement des cellules cancéreuses avec la N,N-diéthyl-2-¢4-(phénylméthyl)-phénoxy!éthanamine (DPPE).

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