Treatment methods using anti-cd22 antibodies

Details Treatment methods using anti-cd22 antibodies Treatment methods using anti-cd22 antibodies

A - Human Necessities

61

K

A61K 39/395 (2006.01) C07K 16/28 (2006.01)

Patent

CA 2475509

The invention concerns treatment methods using anti-CD22 monoclonal antibodies with unique physiologic properties. In particular, the invention concerns methods for the treatment of B-cell malignancies by administering an effective amount of a blocking anti-CD22 monoclonal antibody specifically binding to the first two Ig-like domains, or to an epitope within the first two Ig-like domains of native human CD22 (hCD22).

L'invention concerne des méthodes thérapeutiques utilisant des anticorps monoclonaux anti-CD22 présentant des propriétés physiologiques uniques. L'invention concerne en particulier des méthodes de traitement des malignités des lymphocytes B. Ces méthodes consistent à administrer une quantité efficace d'un anticorps monoclonal bloquant anti-CD22, ledit anticorps se liant de manière spécifique aux deux premiers domaines Ig ou à un épitope à l'intérieur des deux premiers domaines Ig d'un CD22 humain natif (hCD22).

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