Treatment methods using triaryl methane compounds

A - Human Necessities – 61 – K

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A61K 31/165 (2006.01)

Patent

CA 2633805

The use of novel inhibitors of potassium flux is disclosed for the treatment of inflammatory processes, such as multiple sclerosis, insulin-dependent (type I) diabetes mellitus, rheumatoid arthritis, peripheral neuritis and pulmonary hypertension. The compounds are also of use in treating and preventing stroke. These inhibitors have a high specificity for the IK1 channel and greater stability relative to non-fluorine substituted homologues.

L'invention concerne l'utilisation de nouveaux inhibiteurs des canaux potassiques pour le traitement de processus inflammatoires tels que la sclérose en plaques, le diabète sucré insulinodépendant (type I), la polyarthrite rhumatoïde, la névrite périphérique et l'hypertension pulmonaire. Les composés sont également utiles dans le traitement et la prévention des accidents vasculaires cérébraux. Ces inhibiteurs ont une spécificité élevée pour le canal IK1 et une plus grande stabilité que leurs homologues non substitués par le fluor.

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