Treatment of a hemoglobinopathy

Details Treatment of a hemoglobinopathy Treatment of a hemoglobinopathy

A - Human Necessities

61

K

A61K 33/00 (2006.01) A61K 9/72 (2006.01) A61K 31/131 (2006.01) A61K 31/155 (2006.01) A61K 31/198 (2006.01) A61K 31/21 (2006.01) A61K 31/295 (2006.01)

Patent

CA 2251530

Disclosed are methods for treating a patient identified as having a hemoglobinopathy that is characterized by a reduced affinity of hemoglobin for oxygen. The methods involve providing gaseous nitric oxide and/or carbon monoxide for (i) inhalation by the patient or (ii) ex vivo treatment of the patient's erythrocytes. Alternatively, a nitric-oxide-releasing compound can be administered to the patient.

Cette invention concerne des procédés permettant de traiter un patient chez lequel on a décelé une hémoglobinose se caractérisant par une affinité réduite de l'hémoglobine envers l'oxygène. Ces procédés consistent à administrer au patient de l'oxyde d'azote et/ou du monoxyde de carbone gazeux (i) soit par inhalation, (ii) soit par un traitement ex vivo des érythrocytes du patient. Dans un autre mode de réalisation, on peut administrer au patient un composé libérant de l'oxyde d'azote.

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