Treatment of amyotrophic lateral sclerosis with nimesulide

A - Human Necessities – 61 – K

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A61K 31/16 (2006.01) A61K 31/63 (2006.01)

Patent

CA 2505514

The present invention relates to methods for delaying the onset or progression of motor impairment associated with amyotrophic lateral sclerosis in a subject by administering to the subject a therapeutically effective amount of nimesulide. It further provides for a means of detecting and monitoring the progression of amyotrophic lateral sclerosis via a protein biomarker for the disease.

La présente invention concerne des méthodes permettant de retarder l'apparition ou la progression de la détérioration moteur associée à la sclérose latérale amyotrophique chez un sujet, par administration à ce dernier d'une quantité thérapeutiquement efficace de nimésulide. Cette invention concerne également un moyen permettant de détecter et de contrôler la progression de la sclérose latérale amyotrophique par l'intermédiaire d'un biomarqueur de protéine pour cette maladie.

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