Treatment of androgen - deprivation induced osteoporosis

Details Treatment of androgen - deprivation induced osteoporosis Treatment of androgen - deprivation induced osteoporosis

A - Human Necessities

61

K

A61K 9/14 (2006.01)

Patent

CA 2581159

The present invention provides methods for reducing the incidence of, inhibiting, suppressing, and treating androgen-deprivation induced osteoporosis, bone fractures and/or loss of bone mineral density (BMD) in men having prostate cancer, comprising administering to a male human subject having prostate cancer a toremifene and/or its analog, derivative, isomer, metabolite. pharmaceutically acceptable salt, pharmaceutical product, hydrate, N-oxide. or any combination thereof. The present invention also provides methods of treating, preventing, suppressing, inhibiting, or reducing the incidence of hot flashes, gynecomastia, and/or hair loss in a subject, comprising same.

Cette invention porte sur des procédés de diminution de l'incidence, d'inhibition, de suppression et de traitement de l'ostéoporose induite par une carence en androgène, des fractures osseuses et/ou une perte de la densité minérale osseuse (DMO) sur des sujets de sexe masculin souffrant du cancer de la prostate. Ces procédés consistent à administrer à un sujet de sexe masculin souffrant du cancer de la prostate, du torémifène et/ou son équivalent, un dérivé, un isomère, un métabolite, un sel pharmaceutiquement acceptable, un produit pharmaceutique, un hydrate, N-oxyde ou une combinaison quelconque de ceux-ci. Cette invention porte également sur des procédés de traitement, de prévention, de suppression, d'inhibition ou de diminution de l'incidence des bouffées de chaleur, de la gynécomastie et/ou de la perte de cheveux chez un sujet tels que décrits précédemment.

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