Treatment of angiotensin ii related disease

Details Treatment of angiotensin ii related disease Treatment of angiotensin ii related disease

A - Human Necessities

61

K

A61K 31/565 (2006.01) A61K 31/568 (2006.01) A61P 9/00 (2006.01) A61P 11/06 (2006.01) A61P 13/12 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2522300

Use of a compound of formula (I) or a 3-enol C1 to 4 alkanoate ester thereof in the manufacture of a medicament for the treatment of an angiotensin II related disease in humans and animals wherein R1, R2, R5, R6 are the same or different and each is hydrogen or C1 to 4 alkyl; R3 is hydrogen, C1 to 4 alkyl, C2 to 4 alkenyl or C2 to 4 alkynyl; R4 is hydroxyl, C1 to 4 alkanoyloxy, a group of formula (II) or (III) wherein R7 is (CH2)n, where n is an integer of from 0 to 4, R8 is hydrogen, C 1 to 4 alkyl, hydroxy or NH2 and R9 and R10 are the same or different and each is hydrogen or C1 to 4 alkyl; or R3 and R4 together are oxo, ethylenedioxy or propylenedioxy.

La présente invention a trait à l'utilisation d'un composé de formule (I), ou un ester alcanoate en C¿1?-C¿4? 3-énol dans la fabrication d'un médicament pour le traitement d'une maladie liée à l'angiotensine II chez les humains ou les animaux, formule dans laquelle : R¿1?, R¿2?, R¿5?, R¿6?, identiques ou différents, représentent chacun hydrogène ou alkyle en C¿1?-C¿4 ?; R¿3? est hydrogène, alkyle en C¿1?-C¿4?, alcényle en C¿2?-C¿4?, alcynyle en C¿2?-C¿4?; R¿4? est hydroxyle, alcanoyloxy en C¿1?-C¿4?, un groupe de formule (II) ou (III), dans laquelle R¿7? est (CH¿2?)¿n?, où n est un nombre entier de 0 à 4 ; R¿8? est hydrogène, alkyle en C¿1?-C¿4?, hydroxy ou NH¿2 ?; et R¿9? et R¿10?, identiques ou différents, représentent chacun hydrogène ou alkyle en C¿1?-C¿4?; ou R¿3? et R¿4? forment ensemble oxo, éthylènedioxy ou propylènedioxy.

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