Treatment of aphthous ulcers and other mucocutaneous disorders

Details Treatment of aphthous ulcers and other mucocutaneous disorders Treatment of aphthous ulcers and other mucocutaneous disorders

A - Human Necessities

61

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A61K 31/00 (2006.01) A61K 8/44 (2006.01) A61K 9/00 (2006.01) A61K 31/12 (2006.01) A61K 31/20 (2006.01) A61K 31/34 (2006.01) A61K 31/35 (2006.01) A61K 31/365 (2006.01) A61K 31/37 (2006.01) A61K 31/40 (2006.01) A61K 31/41 (2006.01) A61K 31/415 (2006.01) A61K 31/425 (2006.01) A61K 31/436 (2006.01) A61K 31/44 (2006.01) A61K 31/495 (2006.01) A61K 31/505 (2006.01) A61K 31/55 (2006.01) A61K 31/557 (2006.01) A61K 38/04 (2006.01) A61Q 11/00 (2006.01)

Patent

CA 2065496

Treatment of aphthous ulcers and other mucocutaneous disorders comprises contacting the mucocutaneous disorder with an effective amount of an active compound of the formula: Image wherein: R1 is hydrogen, alkyl, phenyl, carboxyl, hydroxyl, alkoxy, carboxyalkyl (i.e. esters), cyano, acylamino, or amino group which may be unsubstituted or substituted by up to two alkyl groups: m is 0, 1 or 2; R2 is alkyl, alkenyl, alkoxy, halgoen, nitro, hydroxy, carboxyl, butadienylene (--CH = CH-CH = CH--) which forms a benzene ring with any adjacent carbon atoms, cyano, carboxyalkyl, trifluoromethyl, or amino group which may be unsubstituted or substituted by at least one alkyl; and R3 is carboxyl, cyano, arylalkoxycarbonyl, alkoxycarbonyl, or carboxamide which may be unsubstituted or substituted by at least one alkyl, and the salts thereof. Treatment compositions may be in the form of a paste, solution, gel, quick-disintegrating tablet, mouthwash, ointment, cream, powder, adhesive patch, aerosolized spray, lozenge, troche, dentifrice, or dental floss that contains an effective amount of the compound.

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