A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/728 (2006.01) A61P 19/02 (2006.01)
Patent
CA 2633957
A method of treating a subject having a musculoskeletal'disorder includes administering to a subject's articular site in need thereof an effective amount of a hyaluronic acid (HA) composition. In one embodiment, the HA composition includes an HA derivative, wherein carboxyl functionalities of the hyaluronic acid derivative are each independently derivatized to include an N- acylurea or O-acyl isourea, or both N-acylurea and O-acyl isourea. In another embodiment, the HA composition includes a crosslinked HA gel that is prepared by reacting an uncrosslinked HA with a biscarbodiimide in the presence of pH buffer in a range of between about 4 and about 8. The composite can optionally include at least one second bioactive agent other than the HA derivative, such as a steroid.
L'INVENTION CONCERNE UN PROCEDE DE TRAITEMENT D'UN SUJET ATTEINT D'UN TROUBLE MUSCULO-SQUELETTIQUES QUI CONSISTE A ADMINISTRER AU NIVEAU DU SITE ARTICULAIRE D'UN SUJET LE NECESSITANT, UNE QUANTITE EFFICACE D'UNE COMPOSITION D'ACIDE HYALURONIQUE (HA). DANS L'UN DES MODES DE REALISATION, LA COMPOSITION D'ACIDE HYALURONIQUE CONTIENT UN DERIVE D'ACIDE HYALURONIQUE, DANS LEQUEL DES FONCTIONNALITES CARBOXYLES DU DERIVE D'ACIDE HYALURONIQUE SONT CHACUNE DERIVEES DE FAÇON INDEPENDANTE DE MANIERE A INCLURE DU N-ACYLUREE OU DE L'O-ACYLE-ISOUREE, OU LES DEUX. DANS UN AUTRE MODE DE REALISATION, LA COMPOSITION D'ACIDE HYALURONIQUE CONTIENT UN GEL D'ACIDE HYALURONIQUE RETICULE QUI EST PREPARE PAR MISE EN REACTION D'UN ACIDE HYALURONIQUE NON RETICULE AVEC UN BISCARBODIIMIDE EN PRESENCE D'UN TAMPON DE PH COMPRIS ENTRE ENVIRON 4 ET 8. LE COMPOSITE PEUT EVENTUELLEMENT CONTENIR AU MOINS UN SECOND AGENT BIO-ACTIF AUTRE QUE LE DERIVE D'ACIDE HYALURONIQUE, PAR EXEMPLE UN STEROIDE.
Bassett Michael J.
Bui Kyle X.
Gooding Tamera B.
Kennedy Stephen J.
Sadozai Khalid K.
Anika Therapeutics Inc.
Gowling Lafleur Henderson Llp
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