Treatment of atherosclerosis

Details Treatment of atherosclerosis Treatment of atherosclerosis

A - Human Necessities

61

K

A61K 39/00 (2006.01) C07K 7/00 (2006.01)

Patent

CA 2580261

The invention relates to the use of a compound comprising the following amino acid sequence X1X2X3X4X5X6X7X8, whereby X1 is an amino acid other than C, X2 is an amino acid other than C, X3 is an amino acid other than C, X4 is an amino acid other than C, X5 is an amino acid other than C, X6 is not present or is an amino acid other than C, X7 is not present or is an amino acid other than C, X8 is not present or is an amino acid other than C and X1X2X3X4X5X6X7X8 is not or does not comprise a 5-mer, 6-mer, 7-mer or 8-mer polypeptide fragment of cholesterine ester transport protein (CETP) or a CETP epitope, whereby the compound has a binding for an antibody specific for the natural CETP glycoprotein, for the production of a means for the prevention and treatment of atherosclerosis, atherosclerosis risk diseases and atherosclerosis consequential diseases.

L'invention concerne l'utilisation d'un composé comportant la séquence acide aminé suivante X1X2X3X4X5X6X7X8, dans laquelle X1 est un acide aminé hors C, X2 est un acide aminé hors C, X3 est un acide aminé hors C, X4 est un acide aminé hors C, X5 est un acide aminé hors C, X6 est inexistant ou est un acide aminé hors C, X7 est inexistant ou est un acide aminé hors C, X8 est inexistant ou est un acide aminé hors C, et X1X2X3X4X5X6X7X8 n'est pas un fragment de polypeptide 5-mer, 6-mer, 7-mer ou 8-mer de la protéine de transfert des esters de cholestérol (CETP) ou n'en contient pas ou bien n'est pas un épitope de la CETP ou n'en contient pas. Ce composé est apte à se lier à un anticorps spécifique de la glycoprotéine naturelle de la CETP pour produire un agent de prévention et de traitement de l'athérosclérose, de maladies à risque de l'athérosclérose et de maladies consécutives à l'athérosclérose.

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