A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/00 (2006.01) A61K 38/19 (2006.01) A61K 38/20 (2006.01) A61K 38/39 (2006.01) C07K 14/47 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2187345
The invention is directed to methods for treating autoimmune diseases such as multiple sclerosis by orally administering a bystander antigen such as myelin basic protein or proteolipid protein in conjunction with a non-interferon polypeptide having Th2-enhancing cytokine activity in such a manner as to induce oral tolerance to the bystander antigen resulting in suppression of the autoimmune response.
L'invention concerne des procédés qui permettent de traiter des maladies auto-immunes telles que la sclérose en plaques par l'administration orale d'un antigène spectateur, tel qu'une protéine de base de la myéline ou une protéine d'un protéolipide, en conjonction avec un polypeptide, ne provenant pas d'un interféron, doté d'une activité cytokine de renforcement des Th2, de façon à induire une tolérance par voie orale à cet antigène spectateur, ce qui entraîne la suppression de la réaction auto-immune.
Chen Youhai
Weiner Howard L.
Smart & Biggar
The Brigham And Women's Hospital
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