Treatment of autoimmune disease using tolerization in...

Details Treatment of autoimmune disease using tolerization in... Treatment of autoimmune disease using tolerization in...

A - Human Necessities

61

K

A61K 35/30 (2006.01) A61K 31/495 (2006.01) A61K 31/50 (2006.01) A61K 38/00 (2006.01) A61K 38/17 (2006.01) A61K 38/28 (2006.01) A61K 38/39 (2006.01) A61K 38/51 (2006.01) B41J 2/21 (2006.01) H04N 1/60 (2006.01)

Patent

CA 2278152

A combination of a mucosally administrable bystander antigen and an orally, enterally, or parenterally administrable methotrexate is employed to make a pharmaceutical formulation and to treat or prevent autoimmune disease. The amounts of bystander antigen and methotrexate are effective in combination to suppress autoimmune response associated with the autoimmune disease.

L'invention concerne une combinaison d'un antigène de voisinage susceptible d'être administré par voie muqueuse et d'un méthotrexate susceptible d'être administré par voie parentérale, entérale ou orale. Cette combinaison est utilisée pour mettre en oeuvre une formulation pharmaceutique et pour traiter ou prévenir des maladies auto-immunes. Les quantités d'antigène de voisinage et de méthotrexate sont efficaces en combinaison pour supprimer une réponse auto-immune associée à la maladie auto-immune.

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