Treatment of barrett's esophagus

Details Treatment of barrett's esophagus Treatment of barrett's esophagus

A - Human Necessities

61

K

A61K 31/551 (2006.01) A61K 31/10 (2006.01) A61K 31/165 (2006.01) A61K 31/18 (2006.01) A61K 31/192 (2006.01) A61K 31/216 (2006.01) A61K 31/222 (2006.01) A61K 31/433 (2006.01) A61K 31/4545 (2006.01) A61K 31/497 (2006.01) A61K 31/55 (2006.01) A61K 31/5513 (2006.01) A61K 31/64 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2633166

The invention relates to the field of biochemistry and medicine. More specifically, the invention relates to the treatment of epithelial changes in the esophagus. Even more specific, the invention relates to the treatment of Barrett's esophagus. The invention provides a method for at least in part decreasing Barrett's esophagus present in an animal comprising at least in part inhibiting Notch pathway activation in said animal. Preferably, said inhibition of Notch pathway activation is accomplished via a g-secretase inhibitor.

La présente invention concerne les domaines de la biochimie et de la médecine. Plus spécifiquement, la présente invention concerne le traitement de modifications épithéliales de l'AEsophage. Encore plus spécifiquement, la présente invention concerne le traitement de l~endobrachyAEsophage. La présente invention concerne une méthode pour diminuer au moins en partie l'endobrachyAEsophage présent chez un animal, ladite méthode comprenant l'inhibition au moins en partie de l'activation de la voie Notch chez ledit animal. De façon préférentielle, ladite inhibition de l'activation de la voie Notch est accomplie par le biais d'un inhibiteur de g-secrétase.

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